首頁 > 促銷活動(dòng) > 新品推薦 N1-甲基假尿苷（N1-Methylpseudouridine）是一種修飾核苷，用于增強(qiáng) mRNA 翻譯。將N1-甲基假尿苷摻入 mRNA可關(guān)閉免疫/eIF2α 磷酸化依賴性翻譯抑制，并增加mRNA上的核糖體的密度，從而顯著促進(jìn)翻譯過程。N1-甲基假尿苷在翻譯能力方面優(yōu)于其他幾種修飾的核苷和相應(yīng)的組合。
輝瑞Pfizer-BioNTech和莫德納Moderna開發(fā)的COVID-19 mRNA疫苗證明了N1-甲基假尿苷修飾在mRNA疫苗開發(fā)中的出色成果，其中尿苷在兩種mRNA疫苗中完全被N1-甲基假尿苷取代。N1-甲基假尿苷修飾的RNA的制備是通過T7 RNA 聚合酶介導(dǎo)的體外轉(zhuǎn)錄酶促摻入相應(yīng)的N1-甲基假尿苷三磷酸（N1-Methylpseudo-UTP）來進(jìn)行的。
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貨號(hào) | 產(chǎn)品名稱 | 描述 |
NU-890 | N1-Methylpseudo-UTP, Sodium salt | 用于相關(guān)研發(fā)使用 |
NU-890-THR | N1-Methylpseudo-UTP, Sodium salt | 用于mRNA生產(chǎn)，提供ml至L規(guī)格 |
RNT-107 | HighYield T7 mRNA Synthesis Kit me1Ψ-UTP | 用于N1-甲基假尿苷修飾(m)RNA的合成 規(guī)格：15 reactions x 20 μl/50 reactions x 20 μl 每個(gè)反應(yīng)產(chǎn)生約100-130 μg N1-甲基假尿苷修飾的RNA |
RNT-115 | HighYield T7 ARCA mRNA Synthesis Kit me1Ψ-UTP | 用于ARCA加帽和N1 甲基假尿苷修飾 (m) RNA的合成 20 μl反應(yīng)產(chǎn)生約30-50 μg RNA |
mRNA合成原料
貨號(hào) | 產(chǎn)品名稱 | 規(guī)格 | CAS號(hào) |
NU-852S | m7GP3G (Monomethylated Cap Analog) | 10 μl (100 mM) | 62828-64-2(acid) |
NU-855S | m2 7,3'-O GP3G (ARCA Cap Analog) | 10 μl (100 mM) | 400806-46-4 (acid) |
NU-1138S | 5-Methyl-CTP | 10 μl (100 mM) | 327174-86-7 (acid) |
NU-988S | N4-Acetyl-CTP | 10 μl (100 mM) | N/A |
NU-1139S | Pseudo-UTP | 10 μl (100 mM) | 1175-34-4 |
NU-972S | 5-Methoxy-UTP | 10 μl (100 mM) | N/A |
NU-1151S | 2-Thio-UTP | 10 μl (100 mM) | 35763-29-2 |
NU-1101S | N6-Methyl-ATP | 10 μl (100 mM) | 3130-39-0 (acid) |
NU-1010 | ATP - Solution | 1 ml (100 mM) | 987-65-5 |
NU-1011 | CTP - Solution | 1 ml (100 mM) | 36051-68-0 |
NU-1012 | GTP - Solution | 1 ml (100 mM) | 36051-31-7 |
NU-1013 | UTP - Solution | 1 ml (100 mM) | 19817-92-6 |
NU-1014S | NTP Bundle (ATP, CTP, GTP, UTP) | 4 x 200 μl (4 x 20 μmol) | |
RNT-008 | T7 RNA Polymerase HC | 50 μl (2 μg/μl) | |
RNT-018 | T7 P&L RNA Polymerase HC | 50 μl (2 μg/μl) | |
RNT-019 | T7 3M RNA Polymerase HC | 50 μl (2 μg/μl) |
RNA合成試劑盒
貨號(hào) | 產(chǎn)品名稱 | 規(guī)格 |
RNT-101 | HighYield T7 RNA Synthesis Kit | 50 reactions x 20 μl |
RNT-201 | HighYield T7 P&L RNA Synthesis Kit | 50 reactions x 20 μl |
mRNA合成試劑盒
貨號(hào) | 產(chǎn)品名稱 |
RNT-004 | Poly(A) Tailing Enzyme Testkit |
RNT-101 | HighYield T7 RNA Synthesis Kit |
RNT-102 | HighYield T7 ARCA mRNA Synthesis Kit |
RNT-103 | HighYield T7 ARCA mRNA Synthesis Kit (m5CTP/Ψ-UTP) |
RNT-104 | HighYield T7 mRNA Synthesis Kit (m5CTP/Ψ-UTP) |
RNT-106 | HighYield T7 mRNA Synthesis Kit (Ψ-UTP) |
RNT-107 | HighYield T7 mRNA Synthesis Kit (me1Ψ-UTP) |
RNT-108 | HighYield T7 mRNA Synthesis Kit (5moUTP) |
RNT-109 | HighYield T7 mRNA Synthesis Kit (s2UTP) |
RNT-110 | HighYield T7 mRNA Synthesis Kit (m5CTP) |
RNT-111 | HighYield T7 mRNA Synthesis Kit (ac4CTP) |
RNT-112 | HighYield T7 mRNA Synthesis Kit (m6ATP) |
RNT-113 | HighYield T7 mRNA Synthesis Kit (m1ATP) |
RNT-114 | HighYield T7 ARCA mRNA Synthesis Kit (Ψ-UTP) |
RNT-115 | HighYield T7 ARCA mRNA Synthesis Kit (me1Ψ-UTP) |
RNT-116 | HighYield T7 ARCA mRNA Synthesis Kit (5moUTP) |
RNT-117 | HighYield T7 ARCA mRNA Synthesis Kit (s2UTP) |
RNT-118 | HighYield T7 ARCA mRNA Synthesis Kit (m5CTP) |
RNT-119 | HighYield T7 ARCA mRNA Synthesis Kit (ac4CTP) |
RNT-120 | HighYield T7 ARCA mRNA Synthesis Kit (m6ATP) |
RNT-121 | HighYield T7 ARCA mRNA Synthesis Kit (m1ATP) |
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